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The cannabinoid receptor CB1, primary target of THC in the brain, is known for mediating the cannabis high. And its counterpart CB2, mainly expressed in immune cells throughout the body, is understood to play an important role in inflammatory processes. These abstractions are accurate as far as they go, but as with anything related to the endocannabinoid system, reality is far more complex.

Project CBD’s recent article on the passing of Raphael Mechoulam noted that the esteemed scientist believed CB2 should be a focus of future cannabinoid science. The CB2 receptor interacts with THC, CBD, endocannabinoids, and other compounds in a multitude of organs including skin and bone.

Recent research — including papers co-authored by Mechoulam well into his 80s — has confirmed that aberrant CB2 signaling is implicated in a raft of autoimmune, neurodegenerative, metabolic, and psychiatric disorders. CB2 is also an increasingly hot topic in cancer research.

In this two-part series, Project CBD will explore some of the latest studies and what they reveal about what we know — and still don’t know — about this ubiquitous, somewhat mysterious cell receptor.

This week: cancer. Next week: cognitive and mood disorders, including some of Mechoulam’s final work before his death in March at the age of 92.

Hemp can be used as a building material in a variety of ways. Here are some ways hemp can be used as a building material: Hempcrete: Hempcrete is a mixture of hemp hurds, lime, and water that can be used as a building material. It is lightweight, strong, and insulating, making it a good choice for walls and roofs.Insulation: Hemp fiber can be used ...

Bioavailability is a measure of how much of a substance is absorbed and available for use in the body. In the case of hemp, the bioavailability of its active compounds, particularly CBD (cannabidiol), can vary depending on the method of administration. Here are some general bioavailability percentages for common methods of consuming CBD: Inhalation...

Water-soluble CBD is a form of cannabidiol that has been modified to dissolve in water, making it easier to mix into beverages or other liquid-based products. Regular CBD oil is hydrophobic (repels water), which makes it difficult to mix into water-based products. Water-soluble CBD products are made by using special technologies that break down the...

Hemp, also known as industrial hemp, is a plant that has been used for thousands of years for a variety of purposes. Here is a brief history of hemp: The first recorded use of hemp dates back to ancient China around 2800 BCE. It was used for making paper, rope, and textiles.By the 16th century, hemp had spread to Europe, where it was used for simil...

Recently my wife returned from a night out with a ringing in one ear and significantly diminished hearing. It was a sure sign of injury caused by standing too close to a speaker. She was upset with herself for being so careless and concerned that the condition would persist. For the next couple days, she got extra sleep to aid recovery, and for good measure took an extra dose or two of CBD.

For many other people of all ages, tinnitus is indeed a chronic condition that has nothing to do with loud ‘80s cover bands in small clubs. Risk factors span a wide range of physical and psychological conditions including concussion, smoking, certain medications, ear infection, high blood pressure, anxiety, depression, and, most commonly, age-related hearing loss.

And it’s not just ringing. Technically, tinnitus (pronounced tih-NITE-us or TIN-ih-tus) is the perception of sound originating from within the nervous system that’s unrelated to external stimulation. Tinnitus can also be experienced as buzzing, whirring, humming, whooshing, clicking, and hissing. Whatever the precise nature of the phantom sound, it often comes with a constellation of symptoms related to the disruption such a condition can bring: sleep problems, difficulty concentrating, low mood, etc. Estimates vary, but tens of millions of people in the United States alone likely suffer from chronic tinnitus.

My wife’s ringing tinnitus did fade, and her hearing gradually improved over the course of a few days. The CBD she took may or may not have helped, but according to a recent survey of tinnitus patients, she wasn’t alone in trying — or at least in being interested in cannabis as a potential remedy.

Auditory & Other Symptoms

The survey, whose findings were published in February 2023 in the Journal of Otolaryngology – Head & Neck Surgery1 evaluated cannabis perceptions and consumption among 45 adult tinnitus patients randomly selected and recruited from an outpatient ear, nose, and throat clinic in Ontario, Canada.

Pinene is a terpene found in many plants, including cannabis. It is named for its distinctive pine aroma and flavor. There are two isomers of pinene: alpha-pinene and beta-pinene. Alpha-pinene is the most common and is found in many strains of cannabis. It is also found in coniferous trees such as pine, fir, and spruce. Beta-pinene is less common b...

I was fortunate to cross paths with Raphael Mechoulam, “the father of cannabis research,” at several science conferences over the years. The most memorable occasion was the 22nd annual meeting of the International Cannabinoid Research Society (ICRS) in Freiburg, Germany, in July 2012. Mechoulam delivered a plenary speech at the symposium, addressing the future of cannabinoid research and key areas of study that should be pursued.

It was exactly fifty years earlier, in 1962, when Mechoulam launched his scientific investigation into the chemistry of cannabis. In 1963, he and Yuval Shvo first reported the molecular structure of cannabidiol (CBD). And the following year Mechoulam coauthored a paper that elucidated the molecular structure of tetrahydrocannabinol (THC). Although he didn’t know it at the time, Mechoulam had lit a slow burning fuse that would detonate a revolution in medical science.

As a young scientist, Mechoulam set out to understand how cannabis works; he ended up unlocking a treasure trove of information about how we work. Known affectionately as “Raphi” to many of the scientists he mentored, Mechoulam tirelessly promoted cooperation between researchers around the world to advance the study of the body’s “endocannabinoid system,” which produces chemicals similar to THC, CBD, and other plant cannabinoids, and mediates their effects.

In 1992, Mechoulam’s research group at Hebrew University in Jerusalem discovered an endogenous THC-like compound that activates receptors in the mammalian brain. He named it “anandamide,” the bliss molecule. And in 1995, Mechoulam and his team identified a second endocannabinoid compound, 2-arachidonoyglycerol or 2-AG for short. Anandamide and 2-AG are part of an internal lipid neurotransmitter system that regulates a wide range of physiological processes, including appetite, mood, pain perception, and immune function.

“Planning Research for the Next Half Century”

“It’s time to plan ahead for the next half a century,” Mechoulam, age 81, told the Freiburg ICRS attendees, who had gathered to honor his 50 years as a pioneer cannabis scientist. Mechoulam cited three specific areas that should be research priorities: CBD, the CB2 cannabinoid receptor, and a cluster of endogenous fatty acid compounds in the brain that he referred to as FAAA’s.

 There are several methods for extracting CBD (cannabidiol) from the cannabis plant. Here are some of the most common methods: CO2 extraction: This method involves using carbon dioxide under high pressure and low temperature to extract CBD from the plant. The resulting extract is pure and potent, making it a popular choice for producing high-q...

CBD, or cannabidiol, is a non-psychoactive compound found in the cannabis plant that has gained popularity in recent years for its potential therapeutic benefits. While research on the effectiveness of CBD for sleep is still ongoing, some studies suggest that it may have the potential to improve sleep in certain individuals. Here are some ways that...

Making a CBD balm is a straightforward process that requires a few simple ingredients and some basic kitchen equipment. Here is a recipe for making your own CBD balm: Ingredients: 1/2 cup coconut oil1/2 cup beeswax1/2 cup shea butter1/2 cup CBD oil (you can adjust this amount based on the desired potency)10-20 drops of essential oils (optional, for...

CBD (cannabidiol) has been touted as a potential natural remedy for various health conditions, including arthritis. Arthritis is a condition characterized by inflammation and pain in the joints, and CBD has anti-inflammatory and analgesic properties that may be beneficial in reducing pain and inflammation associated with arthritis. While research o...

Cannabidiol (CBD) is a cannabinoid that has shown potential benefits for acne-prone skin. CBD has anti-inflammatory properties that can help reduce the production of sebum, the oily substance that can contribute to acne. It also has antibacterial properties that can help kill the bacteria responsible for acne breakouts. Additionally, CBD can help s...

At first glance, Cannabis Textiles is a quiet, unassuming book, without slick, staged photos or superlative descriptions of indigenous cultures. Such simplicity reflects the book’s inner beauty, which documents the history of a disappearing handcraft, that of traditional hemp cultivation and fabric production.

Skoglund’s book focuses primarily on indigenous hemp cultures in Europe and Asia. Her passion for hemp was lit while pursuing her Master’s thesis studies at the Swedish School of Textiles, University of Borås and in Uppsala, Sweden in the 1970s, when she discovered a significant absence of recorded information on traditional hemp craft.

“It was almost taboo to talk about hemp, because it was intimately connected to drugs and was banned in Sweden [until 2003],” she told Project CBD.

Skoglund began to weave with hemp yarn herself, while scouring the historical record for mentions of the craft. She used DNA and microscopic testing methods to determine the fiber content of a number of antique textiles kept in museums and archives, and found many that were made completely or partially from hemp fibers. 

A Bast Fiber Plant

Long before 1842, when William O’Shaughnessy brought psychoactive cannabis indica from India to the West, a type of cannabis commonly known as hemp was grown in kitchen gardens across Europe and East Asia, “near castles and monasteries, mansions and simple farms,” writes Skoglund. Hemp, a bast fiber plant, was cultivated for its seeds and medicinal properties, but mainly for its fiber. Fiber from other bast plants, such as flax and hops, was often blended with hemp fiber.

Have you heard of Celtic Hemp? In a recently published paper in Cannabis and Cannabinoid Research, Dr. John M. McPartland and Saoirse E. O’Sullivan trace hemp’s prehistoric journey from Asia to Hibernia — now modern-day Ireland. Like much of Europe, cannabis arrived in Ireland when written records were scarce.

The authors rely on archeological, linguistic, and pollen analyses as they document the migration of cannabis across Europe. Ancient pollen, extracted from mud, contains signals from cannabis’s past. Seeds from crops and rare archeological artifacts provide additional clues attesting to hemp’s intimate relationship with humankind.

Thousands of years ago, the medicinal properties of cannabis were remarked in ancient texts. At this time, humans living closer to the plant’s area of origin on the Tibetan plateau relied on fibers from cannabis stalks for textiles. By 400 BCE, humans left evidence of cannabis where Celtic culture is thought to have originated.

The Birthplace of Celtic Culture

People of the Yamnaya culture, encompassing modern Ukraine, utilized cannabis crops earlier than the Celtic culture that emerged in Europe during the Iron Age (1200-550 BC). Cannabis fibers and water-logged seeds first appeared in Hallstatt, a region near modern Austria, which is considered the birthplace of the Celtic peoples.

But the words used for cannabis and hemp were all borrowed from another culture. The lack of an ancestorial word for hemp or cannabis in Proto-Celtic implies that the inhabitants of Halsttatt spoke a language unrelated to early precursors of the Celtic lexicon.