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Project CBD Newsletter: Plant-Derived Extracts Outperform Single-Molecule THC, Mental Health Research into Cannabis & Psychedelics, and the Neuroscience of Psychedelic Entity Encounters

This week’s newsletter covers whole-plant cannabis extracts versus isolated THC for chronic pain, the intersection of mental health and cannabis use, the politics of marijuana criminalization, and new perspectives on how psychedelics affect the mind.
Noteworthy Read
Plant-Derived Cannabis Extracts More Effective Than Dronabinol in Elderly Patients with Chronic Pain (NORML)
A recent study out of Germany found that whole-plant cannabis extracts outperformed isolated THC in managing chronic pain among older adults, suggesting that the combined effects of cannabinoids and terpenes may offer more balanced and effective relief.
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More Noteworthy Reading
Trump Deports Immigrants Over Marijuana Violations (Marijuana Moment)
A federal deportation list, which the Trump Administration published to highlight the “worst of the worst” immigrants targeted by federal authorities, reportedly includes nearly 100 individuals flagged for simple marijuana possession.
Cannabis Use Exacerbates Paranoia in Survivors of Chaotic Childhoods (PsyPost)
A new study suggests that cannabis may intensify feelings of paranoia in people who experienced unstable or traumatic childhood environments. The findings point to the importance of context, and how personal history and emotional patterns can shape the way cannabis is experienced.
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Emotional Regulation and Cannabis Use in Young People (Frontiers)
Research exploring young people’s cannabis use suggests it may be closely tied to how individuals manage stress and emotions. Some of the key areas of behavioral impact included impulse control, goal-directed behaviour, and nonacceptance of emotions.
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Why Psychedelics Make Us Vulnerable to Conspiracy Theories (Medium)
This article explores how psychedelic states can open the mind to new perspectives, but also make people more suggestible to uncertain or misleading narratives. It highlights the importance of grounding, integration, and critical thinking alongside expanded awareness.
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Why the Brain Keeps Inventing Entities (Medium)
An exploration of how the human mind naturally creates meaning, patterns, and even perceived “entities,” especially in altered states. The article connects neuroscience, psychology, and psychedelic experiences to explain why these encounters can feel so real and significant.
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A heartfelt thank you to all the CBD brands whose generous support allows Project CBD to shine a light on the research and stories shaping the future of plant medicine. We’re grateful to have such dedicated partners by our side.
The post Project CBD Newsletter: Plant-Derived Extracts Outperform Single-Molecule THC, Mental Health Research into Cannabis & Psychedelics, and the Neuroscience of Psychedelic Entity Encounters appeared first on Project CBD.
